Tesamorelin

Tesamorelin is a 44-residue GHRH analog modified at the N-terminus with a trans-3-hexenoic acid acyl group on Tyr1. The peptide sequence corresponds to GHRH(1-44) (UniProt P01286, residues 32–75). Empirical formula C₂₂₁H₃₆₆N₇₂O₆₇S; MW 5135.85 Da.

Reconstitution. For in-vitro laboratory handling, dissolve with bacteriostatic water (0.9% benzyl alcohol). Compound is hygroscopic — handle in low-humidity conditions and re-cap immediately.

Stability profile. Lyophilized: stable at room temperature for up to 30 days sealed; long-term storage at -20 °C recommended. Reconstituted material: stable at 2–8 °C for up to 14 days.

Selected primary literature.
- Ferdinandi ES et al., 2007, Basic Clin Pharmacol Toxicol 100(1):49 — preclinical in-vitro structural and DPP-4-stability characterization of tesamorelin.

What remains uncharacterized: concentration-response relationships in any specific in-vitro model system are not implied here. The literature cited above describes molecular-level observations only.

For research use only. Not for human or animal consumption.

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