PT-141 (Bremelanotide)

PT-141 is a cyclic heptapeptide with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH. The Asp5–Lys10 lactam bridge constrains the α-MSH(4-10) pharmacophore. Empirical formula C₅₀H₆₈N₁₄O₁₀; MW 1025.17 Da (PubChem CID 9941844).

Reconstitution. For in-vitro laboratory handling, dissolve with bacteriostatic water (0.9% benzyl alcohol). Compound is hygroscopic — handle in low-humidity conditions and re-cap immediately.

Stability profile. Lyophilized: stable at room temperature for up to 30 days sealed; long-term storage at -20 °C recommended. Reconstituted material: stable at 2–8 °C for up to 14 days.

Selected primary literature.
- Diamond LE et al., 2004, J Sex Med 1(2):199 — structural and in-vitro receptor-binding characterization of the melanocortin-receptor pharmacophore (preclinical).

What remains uncharacterized: concentration-response relationships in any specific in-vitro model system are not implied here. The literature cited above describes molecular-level observations only.

For research use only. Not for human or animal consumption.

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