MT-2 (Melanotan II)

Melanotan II is the C-terminal-amide congener of the same Asp5–Lys10 lactam scaffold used in PT-141. Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂. Empirical formula C₅₀H₆₉N₁₅O₉; MW 1024.18 Da (PubChem CID 16133844).

Reconstitution. For in-vitro laboratory handling, dissolve with bacteriostatic water (0.9% benzyl alcohol). Compound is hygroscopic — handle in low-humidity conditions and re-cap immediately.

Stability profile. Lyophilized: stable at room temperature for up to 30 days sealed; long-term storage at -20 °C recommended. Reconstituted material: stable at 2–8 °C for up to 14 days.

Selected primary literature.
- Al-Obeidi F et al., 1989, J Med Chem 32(8):2555 — original design and structural characterization of the cyclic lactam α-MSH(4-10) pharmacophore (preclinical in-vitro receptor-binding study).

What remains uncharacterized: concentration-response relationships in any specific in-vitro model system are not implied here. The literature cited above describes molecular-level observations only.

For research use only. Not for human or animal consumption.

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