GHK-Cu

GHK-Cu is a 1:1 complex of the tripeptide glycyl-L-histidyl-L-lysine with a Cu(II) ion. The metal coordinates via the histidine imidazole N3, the N-terminal amine, and the deprotonated peptide bond nitrogen between Gly and His. Empirical formula C₁₄H₂₄N₆O₄·Cu; MW 403.93 Da (PubChem CID for the Cu complex: 24855608).

Reconstitution. For in-vitro laboratory handling, dissolve with sterile water. Compound is hygroscopic — handle in low-humidity conditions and re-cap immediately.

Stability profile. Lyophilized: stable at room temperature for up to 30 days sealed; long-term storage at -20 °C recommended. Reconstituted material: stable at 2–8 °C for up to 14 days.

Selected primary literature.
- Pickart L, 1973, FEBS Lett 31(2):151 — original isolation and structural characterization of the tripeptide from human plasma.
- Pickart L & Margolina A, 2018, Int J Mol Sci 19(7):1987 — review of the structural coordination chemistry of GHK-Cu(II).

What remains uncharacterized: concentration-response relationships in any specific in-vitro model system are not implied here. The literature cited above describes molecular-level observations only.

For research use only. Not for human or animal consumption.

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