Cagrilintide

Cagrilintide is a 37-residue acylated amylin / calcitonin-family analog. Disulfide bond between Cys2 and Cys7; C-terminal amide; gammaGlu-2xOEG-C20-diacid acyl side chain attached at the N-terminal Lys. MW 4419 Da.

Reconstitution. For in-vitro laboratory handling, dissolve with bacteriostatic water (0.9% benzyl alcohol). Compound is hygroscopic — handle in low-humidity conditions and re-cap immediately.

Stability profile. Lyophilized: stable at room temperature for up to 30 days sealed; long-term storage at -20 °C recommended. Reconstituted material: stable at 2–8 °C for up to 14 days.

Selected primary literature.
- Lau J et al., 2021, J Med Chem 64(13):8967 — discovery and structural characterization of cagrilintide as a long-acting amylin analog (preclinical).

What remains uncharacterized: concentration-response relationships in any specific in-vitro model system are not implied here. The literature cited above describes molecular-level observations only.

For research use only. Not for human or animal consumption.

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