HMG (Human Menopausal Gonadotrophin)

Menotropin is a urinary extract containing follicle-stimulating hormone (heterodimeric αβ glycoprotein) and luteinizing hormone (heterodimeric αβ glycoprotein) in an approximately 1:1 IU ratio. Both molecules share the 92-residue α-subunit (UniProt P01215) and differ in their β-subunits (FSH-β UniProt P01225; LH-β UniProt P01229). The molecular-weight distribution centers near 30 kDa per heterodimer, with substantial glycoform heterogeneity.

Reconstitution. For in-vitro laboratory handling, dissolve with bacteriostatic water (0.9% benzyl alcohol). Compound is hygroscopic — handle in low-humidity conditions and re-cap immediately.

Stability profile. Lyophilized: stable at room temperature for up to 30 days sealed; long-term storage at -20 °C recommended. Reconstituted material: stable at 2–8 °C for up to 14 days.

Selected primary literature.
- Pierce JG & Parsons TF, 1981, Annu Rev Biochem 50:465 — review of the structural relationships among the pituitary glycoprotein hormones.
- Lunenfeld B, 2004, Hum Reprod Update 10(6):453 — historical structural-characterization review of urinary menotropin preparations.

What remains uncharacterized: concentration-response relationships in any specific in-vitro model system are not implied here. The literature cited above describes molecular-level observations only.

For research use only. Not for human or animal consumption.

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