ACE-031

ACE-031 is a recombinant Fc-fusion in which the extracellular domain of activin receptor type IIB (ActRIIB) is genetically linked to a human IgG1 Fc. The construct has a reported molecular weight of approximately 79 kDa (per Acceleron Pharma WO/2008/097541). The Fc dimer geometry gives the molecule a homodimeric ActRIIB-ECD arrangement.

Reconstitution. Solubility is highest in 0.1% acetic acid or in DMSO; bacteriostatic water suffices for most applications. Avoid alkaline buffers (pH > 8) for prolonged exposure.

Stability profile. Lyophilized: stable at room temperature for up to 30 days sealed; long-term storage at -20 °C recommended. Reconstituted material: stable at 2–8 °C for up to 14 days.

Selected primary literature.
- Cadena SM et al., 2010, Skelet Muscle 1(1):15 — structural characterization of the ActRIIB-Fc fusion (preclinical in-vitro ligand-trap binding study).

What remains uncharacterized: concentration-response relationships in any specific in-vitro model system are not implied here. The literature cited above describes molecular-level observations only.

For research use only. Not for human or animal consumption.

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