Melanotan 1 (MT-1)

Melanotan 1 (afamelanotide) is a linear 13-residue α-MSH analog with the sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂. Substitutions at residues 4 (Nle) and 7 (D-Phe) confer resistance to enzymatic cleavage. Empirical formula C₇₈H₁₁₁N₂₁O₁₉; MW 1646.85 Da.

Reconstitution. For in-vitro laboratory handling, dissolve with bacteriostatic water (0.9% benzyl alcohol). Compound is hygroscopic — handle in low-humidity conditions and re-cap immediately.

Stability profile. Lyophilized: stable at room temperature for up to 30 days sealed; long-term storage at -20 °C recommended. Reconstituted material: stable at 2–8 °C for up to 14 days.

Selected primary literature.
- Sawyer TK et al., 1980, PNAS 77(10):5754 — original structural design and in-vitro receptor-binding characterization of the [Nle4,D-Phe7]-α-MSH analog (preclinical).

What remains uncharacterized: concentration-response relationships in any specific in-vitro model system are not implied here. The literature cited above describes molecular-level observations only.

For research use only. Not for human or animal consumption.

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