GDF-8 (Myostatin)

Mature GDF-8 (myostatin) is a disulfide-linked homodimer of 109-residue monomers derived from the proGDF-8 precursor (UniProt O14793, residues 268–375). The dimer is stabilized by an inter-chain disulfide bond between Cys339 residues, with three additional intra-chain disulfides per monomer forming the characteristic TGF-β-superfamily cystine-knot fold.

Reconstitution. Solubility is highest in 0.1% acetic acid or in DMSO; bacteriostatic water suffices for most applications. Avoid alkaline buffers (pH > 8) for prolonged exposure.

Stability profile. Lyophilized: stable at room temperature for up to 30 days sealed; long-term storage at -20 °C recommended. Reconstituted material: stable at 2–8 °C for up to 14 days.

Selected primary literature.
- Cotton TR et al., 2018, EMBO J 37(2):367 — crystal structure of the latent proGDF-8 dimer (preclinical structural biology).

What remains uncharacterized: concentration-response relationships in any specific in-vitro model system are not implied here. The literature cited above describes molecular-level observations only.

For research use only. Not for human or animal consumption.

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