Mazdutide

Mazdutide (IBI362 / LY3305677) is a 29-residue acylated oxyntomodulin analog with dual GLP-1 / glucagon receptor agonism. The acyl side chain is a C18-fatty-diacid attached at K10 via gammaGlu-2xOEG linkers. Reported MW ~4093 Da.

Reconstitution. For in-vitro laboratory handling, dissolve with bacteriostatic water (0.9% benzyl alcohol). Compound is hygroscopic — handle in low-humidity conditions and re-cap immediately.

Stability profile. Lyophilized: stable at room temperature for up to 30 days sealed; long-term storage at -20 °C recommended. Reconstituted material: stable at 2–8 °C for up to 14 days.

Selected primary literature.
- Ji L et al., 2021, Lancet Reg Health West Pac 14:100214 — structural and pharmacokinetic preclinical characterization of mazdutide (LY3305677).

What remains uncharacterized: concentration-response relationships in any specific in-vitro model system are not implied here. The literature cited above describes molecular-level observations only.

For research use only. Not for human or animal consumption.

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